Top Trends, Presentations, and Takeaways from CYTO 2018

CYTO, the International Society for the Advancement of Cytometry (ISAC)’s annual meeting wrapped up earlier this month in the exciting city of Prague, Czech Republic. As the premier meeting for showcasing the state of the art and science of cytometry, CYTO and its members revealed no small number of exciting developments in cytometry and beyond. We’re just now getting around to sharing all we saw and heard at the meeting. Some of our favorite presentations and observations include: More »

April 16, 2018  |  Conferences, Events, viSNE

AACR Bulletin: Don’t Miss our Booth, Key Presentations in Chicago

cytobankbooth3603If you’re at the Annual Meeting of the AACR (American Association for Cancer Research), come visit our team in person, get some hands-on help, and see the latest developments in how our cloud-based Machine Learning analysis platform can help accelerate more detailed discovery.
Meet us at Booth #3603
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Posters and Talks:

We’re excited to see the breadth and depth of presentations throughout the conference program that include work done on the Cytobank platform. In addition to our very own team’s presentation on rapid RNA-seq biomarker discovery, many others have used of Cytobank in their discoveries. See here for a sampling of posters and talks submitted to us by our users. More »

April 11, 2018  |  Announcements, Conferences, Flow Cytometry

Announcing Cytobank’s Collaboration with Cytek Biosciences

We’rCytekLogoe excited to announce a new collaboration with Cytek, makers of the innovative CytekTM Aurora Flow Cytometer. Cytek’s Aurora and Cytobank’s next-generation analytics platform have united in their goal to make high-dimensional data and its subsequent machine learning analysis more accessible to more scientists.

  • Aurora’s unique optical design combined with spectral unmixing delivers quality, high-dimensional data where rare and dim populations can be easily resolved, regardless of sample complexity.
  • Cytobank’s algorithms simplify visualization and analysis of high-dimensional unmixed data and allow you to quickly share discrete insights from these data.

Here are two specific examples of how you can apply our combined solutions to enable faster, more highly-resolved discoveries: More »

December 20, 2017  |  Conferences, viSNE

ASH Annual Meeting Report: Key Takeaways and Developments

We were excited to attend the American Society of Hematology meeting this month in Atlanta. Despite the conference beginning with the arrival of an unexpected winter storm, many leading scientists and clinicians congregated to present and discuss cutting-edge research in hematology.

The Cytobank platform was used by many who attended and presented and we were proud to contribute to these scientific advances. Highlights for us were:

  1. A multiparametric approach, “pharmacoscopy:” (a single-cell drug-response profiling approach that utilizes IF, automated microscopy, and image analysis, as detailed by Vladimer, Snijder et al., Nat. Chem. Biol. 2017) identified targetable drug pathways in CLL patients. Interestingly, the way that these authors use image morphology to quantify cell death is similar to what Ross Marklein from the FDA’s Center for Biologics Evaluation and Research (CBER) presented at BMES using Cytobank on imaging morphology data. In our consulting services, we’re excited to work with our customers on projects that integrate multiple data types, such as this work presented at ASH.
  2. Next Generation Sequencing (NGS) and its application in the clinic today was widely discussed. Similar to high dimensional cytometry analyses, developing reproducible and efficient bioinformatics analysis pipelines was identified as a major challenge to dissecting the large volume of data generated by NGS. During the late breaking abstract session, Dr. Tim Grob, presented data from a large prospective clinical trial demonstrating that NGS MRD detection can predict relapse and survival in newly diagnosed AML.
    Challenges for clinical use of Whole Exome Sequencing presented by Dr. Haferlach
    Challenges for clinical use of Whole Exome Sequencing presented by Dr. Haferlach.

     

  3.  Cytobank in action: Numerous posters and presentations used Cytobank to investigate immune system response to cancer, dysplasia, and other blood disorders. Some examples include:

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Tanaya Shree, Stanford University Medical Center, presenting “
Altered Peripheral Immune Phenotypes in Mantle Cell Lymphoma Survivors”. Here, CITRUS helped identify alterations of T cell subsets on MCL PBMC samples as compared to healthy donor samples.

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Bita Sahaf:
“Ibrutinib Inhibits cGVHD Pathogenic Pre-Germinal center B-cells and Follicular Helper Cells While Preserving Immune Memory and Th1 T-cells”

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Thomas Coats:
Neoantigens in MDS Are Associated with Two Novel CD4+ T Cell Subsets and Improved Overall Survival”

Learn more about how you can:

 

October 23, 2017  |  Announcements, Conferences, DROP, viSNE

Biomedical Engineering Society Conference Review: Using viSNE on Single-cell Image Data for Improved Characterization of Immunotherapeutic Stem Cells

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Recently at the Biomedical Engineering Society MeetingRoss Marklein from the FDA’s Center for Biologics Evaluation and Research (CBER), presented a poster using viSNE in Cytobank on single-cell image data to characterize the function of mesenchymal stem cells (MSCs) used for cell therapy in autoimmune disease.
More »